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The OXPHOS proteins comprise five complexes (IV) embedded in the inner mitochondrial membrane that are uniquely controlled by mitochondrial DNA (mtDNA) and the nuclear DNA (nDNA)

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Across multiple disease areas, discussions increasingly focused not only on whether treatments work under controlled study conditions, but also on how they perform in diverse patient populations, how they impact quality of life, and how healthcare systems can generate evidence that supports more informed clinical, regulatory, and reimbursement decisions