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The occurrence of reduced exercise performance is not documented in any previous reviews but seems to be a common effect as it is reported in every study where it has been tested (although we cannot rule out publication bias, i.e., lack of publishing where no such symptoms have occurred)

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This review summarizes new targets, including proteins, small molecular metabolites, and epigenetics regulators

That said, research has not confirmed that taking doses of vitamin B-12 or methionine above the recommended amount helps a person lose weight

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