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Complementary Mechanisms When combined, these compounds create a multi-faceted approach to NO enhancement: Increased Substrate Availability - As described above, L-citrulline effectively raises plasma L-arginine levels, providing more raw material for nitric oxide synthase (NOS) enzymes to produce NO

This improvement was linked to increased hippocampal expression of the memory-associated genes cAMP-responsive element-binding protein and brain-derived neurotrophic factor [216]

For extended storage, freeze at -20C whenever possible

Microarray analysis of gene expression in rat cortical neurons exposed to hyperbaric air and oxygen

doi: 10.3390/ijms21186973

However, this could potentially change in the future