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Cells possessing this ability of enhanced invasion start to invade surrounding tissue with the support of proteolytic enzymes secreted to degrade the ECM and provide a route of invasion (119)

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Doglio and colleagues isolated Tregs from the peripheral blood mononuclear cells (PBMC)s of a healthy donor, and expanded them using IL-2 and rapamycin to generate a second-generation anti-CD19 CAR