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In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig

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PMID 11916755

Additionally, as in cell cultures, liraglutide suppressed CD36 and ACAT1 expression in macrophages but did not affect ABCA1 expression

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