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When administered centrally (icv), fatty-acyl GIP decreases body weight and food intake in HFD-fed wildtype mice but not in mice with CNS deletion of Gipr (179)

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229,230 Conclusion In summary, GLP-1RAs and dual-receptor agonists targeting both GLP-1 and GIP receptors have introduced significant advancements in the management of endocrine and metabolic disorders and their associated complications, establishing themselves as central therapeutic modalities within this domain