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The upregulation of the expression of glutamine transporters and increased expression of GOT1/2 in the TCA cycle in KRAS-mutant tumors are promising targets for the treatment of such cancers

2b) while S914 is not conserved

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In addition to its role in fatty acid transport, carnitine in the mitochondrial matrix can act as a buffer by binding to accumulating Acetyl-CoA generated from the glycolytic pathway