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The repositioning of N387 in turn enables the formation of an electrostatic network with NTD residues that fix the down state (Extended Data Fig

Assessment of long-term management strategies

Bloating and Gas: Often caused by the breakdown of unabsorbed glutathione in the large intestine

Targeted therapies, including TNF inhibitors, may improve both PsA and metabolic parameters [63]

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Antimicrobial responses to enteric pathogens are also modulated by commensal gut colonising bacteria