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Whereas normal physiological wound healing depends on low levels of ROS and oxidative stress, overexposure to oxidative stress leads to impaired wound healing

Andrade M, Dunsmoor-Su R, Huvinen E et al

Therefore, different studies demonstrate that GS inhibition/downregulation can restrain tumor growth and resistance to radiotherapy and chemotherapy, suppressing glutamine-dependent nucleotide synthesis [5, 208,209,210,211,212]

These assays typically involve expressing the receptor in cell lines and measuring downstream signaling events, such as cyclic AMP production or calcium flux, when the test molecule is added

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