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Trauma exposure also induces intestinal inflammation (increased CD45 + leukocytes, CD68 + macrophages, and CD3 + T cells and upregulated phosphorylated Stat3 and NF-B) signaling

and given that they tend to be more demanding due to their rapid growth, it is not surprising that newborns fed with PN without supplements will reach very low carnitine levels after two weeks of life 6

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The Hcy induced redox imbalance can compromise aldosterone synthase (low aldosterone) and 11beta hydroxylase (low cortisol), both mitochondrial based (Hggstrm & Richfield, 2014)

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