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The peptide appears to attract these cells to the wound site and coordinates their activity in repairing the damage

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When we combined xCT overexpression with GPX4 deletion, we found that elevated Cys availability rescues GPX4-deficient cells from ferroptotic cell death (Fig

Intriguingly, the expression of GPD2 (and also AIFM2, which encodes FSP1) showed a mutually exclusive expression pattern, whereas DHODH showed a positive correlation with LDHB in a large collection of cancer cell lines (Supplementary Fig

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These differences help explain why both compounds remain valuable for complementary aspects of cellular health and longevity strategies, despite their differences