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Advice is available for management of laryngopharyngeal reflux (Krause et al, 2022), and if neurogenic chronic cough seems likely, referral for neuromodulators (opioids with or without cough suppressants), voice therapy, superior laryngeal nerve block or laryngeal botox can be considered (Wamkpah et al, 2022)

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, the covalent binding of NAPQI to the thiol groups of critical cellular proteins (following glutathione depletion), oxidative stress induced directly by NAPQI or via coproduction of reactive oxygen species (superoxide radical and hydrogen peroxide) through redox cycling between the paracetamol semiiminoquinone radical and NAPQI) (1, 2), and vice versa, these processes counteraction may be involved in BPC 157 beneficial effects