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Unfortunately, a phase II clinical trial of UBX0101 (NCT03513016) was completed in patients with osteoarthritis and the promising results observed (Table 1), in vitro and in vivo, have not been up to the expectations in treated patients, leading only to a decrease of pain, without a significant improvement of the disease 30

Studies, such as those referenced on Sage Journals, have shown promising results with these herbal antimicrobials, supporting their use as part of a comprehensive treatment plan

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Researchers have also utilized mice models to explore the underlying mechanism of AOD 9604

Response: Although we acknowledge the applicant's concerns regarding the descriptor for C1739, we do not agree that the device category code should be withdrawn and replaced with a new code effective January 1, 2026, for the following reasons: First, per the applicant's request prior to CY 2026 rulemaking, CMS revised the descriptor for C1739 to read, effective October 1, 2025: Tissue marker, uniquely detectable and identifiable with probe/sensor, any method (implantable), with delivery system

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