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Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)

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The magnitude of weight reduction by CagriSema might be even more pronounced with longer follow-up since no evidence of a plateau effect was demonstrated up to the end of treatment at 32 weeks [10]

This is fundamentally different from the injection site profile of tirzepatide or semaglutide , which generally produce minimal injection site reactions

There, the functional recovery, muscle size recovery, and oxidative stress, may be particularly illustrative

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