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Parkin DM, Mesher D, Sasieni P

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The glutathione (GSH) antioxidant system is foremost among the cellular protective mechanisms

This ERK-without-Akt profile supports cellular proliferation and survival while maintaining cells in a proliferative rather than differentiated state contrasting sharply with IGF-1s PI3K/Akt/mTOR-dominant signalling, which drives protein synthesis and differentiation