Uses * Control blood sugar in type 2 diabetes * Reduce risk of cardiovascular events in some diabetic patients * Promotes weight loss * Sometimes used off-label for obesity management Mechanism of action Ozempic works by: * Increasing insulin release when blood glucose is high * Reducing glucagon secretion * Slowing gastric emptying * Reducing appetite Administration * Given as a subcutaneous injection * Usually injected once weekly * Common injection sites: * Abdomen * Thigh * Upper arm Common side effects * Nausea * Vomiting * Diarrhea * Constipation * Abdominal pain * Loss of appetite Serious adverse effects * Pancreatitis * Gallbladder disease * Severe dehydration * Kidney injury * Hypoglycemia (especially with insulin or sulfonylureas) * Possible thyroid C-cell tumor risk Contraindications * Personal or family history of medullary thyroid carcinoma * Multiple endocrine neoplasia type 2 (MEN2) * Severe hypersensitivity to semaglutide Monitoring * Blood glucose and HbA1c * Weight * Renal function * Signs of pancreatitis Important points * Not used for type 1 diabetes * Should be combined with diet and exercise * Dose is increased gradually to reduce gastrointestinal side effects * Stopping suddenly may lead to weight regain or worsening glucose control Drug interactions Caution with: * Insulin * Sulfonylureas * Oral medications affected by delayed gastric emptying To view or add a comment, sign in More Relevant Posts Exercise caution before popping a pill
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Furthermore, many studies rely on surrogate endpoints, such as oocyte maturation, fertilization rate, or oxidative stress biomarkers, rather than on clinically meaningful reproductive outcomes, such as the live birth rate
Gradual Dosage Adjustment Dosage increases are carefully managed to reduce side effects like nausea or digestive discomfort
