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Genes involved in tissue repair, collagen synthesis, and antioxidant protection see increased activity, while genes associated with inflammation, tissue breakdown, and cellular aging see reduced expression

This senescence can further enhance inflammation by releasing senescence-associated secretory phenotype (SASP) factors, which induces a feedback loop between inflammation and telomere attrition (Herranz and Gil, 2018)

Splitting into twice-daily injections is reasonable at higher daily totals (e.g., 250 mcg AM + 250 mcg PM at a 500 mcg/day total)

& Goeddel, D.V

Marcombe et al

SIRT1 deacetylates NF-B, suppressing its transcriptional activity, which ultimately reduces macrophage infiltration and the release of pro-inflammatory cytokines [38]