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5 The procedure is, therefore, SS aptly called percutaneous collagen induction therapy and has also been used in the treatment of photo-aging

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The mechanism involves upregulation of matrix metalloproteinases (MMPs) and their inhibitors, which remodel collagen in a more organized way than unassisted healing

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As found here, PAT is a noncompetitive TGR inhibitor with a K i value in the low nanomolar range, showing that PAT is by three orders of magnitude a better inhibitor of TGR than of PFK, which has an IC 50 of 16 M [65]