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The NMR signals originate from the partner protein, which is colored orange (left)

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Unlike ascorbic acid, which is water-soluble, ascorbyl palmitate can cross cell membranes and other biological barriers

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Further studies using virus-mediated gene knockout and chemogenetic approaches have confirmed that knocking out the Shank3 gene specifically in interneurons is sufficient to cause hyperexcitability in pyramidal neurons and sensory hypersensitivity (92)