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Moreover, genetic and environmental factors significantly contribute to the impairment of glucose tolerance and account for the interindividual susceptibility to disturbed glucose homeostasis induced by the cortisol excess ( Pathophysiology of glucocorticoid-induced insulin resistance and diabetes mellitus in patients with Cushings disease In humans, glucocorticoid hormones are represented primarily by cortisol produced in the adrenal glands

Ramirez D, Caballero J

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