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Adequate protein intake (approximately 1.21.6 g per kg body weight daily for most adults) is important during a calorie deficit to help preserve muscle mass

In terms of blood pressure management, GLP-1 RAs modulate the renin-angiotensin-aldosterone system (RAAS), reduce vascular resistance, and improve vascular relaxation, effectively lowering SBP 39,40,41

Masaki T, Wang Y, DiGiovanna JJ, Khan SG, Raffeld M, Beltaifa S et al

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Randomised placebo-controlled trial of Orlistat for weight loss and prevention of weight regain in obese patients