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Nonthyroidal illness syndrome (NTIS) is the state in which inflammation causes negative changes to thyroid hormone including low T3 and increased reverse T3 (rT3)

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Topal, S., Vasseur, P., Radman-Livaja, M

Specifically, extracts from the viscera of sea cucumbers (Stichopus japonicus viscera extracts, VF) have been shown to stimulate the ERK signaling pathway, downregulate melanin synthesis, and enhance collagen synthesis 42

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