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Individuals with a history of medullary thyroid cancer or Multiple Endocrine Neoplasia Type 2 should avoid semaglutide entirely, as GLP-1 agonists carry a theoretical increased risk of thyroid cell proliferation

It decreases peristaltic movements (wave-like contractions) in the digestive tract and delays gastric emptying

In the literature, there appear to be ten other cases of colonic ischemia associated with GLP-1 agonist or GLP-1/GIP dual agonist use (Table 3) [12,13,14,15,16,17,18,19,20,21]

Monami, M