can i stop glp 1 cold turkey Most Patients Keep Weight Off With Fewer GLP-1 Shots, Study Finds Safely stopping GLP-1 medication

doi: 10.1016/j.cmet.2020.11.016 78 MalinskaDSzymaskiJPatalas-KrawczykPMichalskaBWojtalaAPrillMet al

This increase may lead to a reduction in the projection of the neural repair protein GLP-1, subsequently downregulating the expression of c-Fos, TrkB, and BDNF

Bone Density Rapid weight loss of 14% or more over 34 months is associated with meaningful reductions in bone mineral density, particularly at weight-bearing sites like the hip and femur

Goodman & Gilmans The Pharmacological Basis of Therapeutics

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Why this is HUGE: - Obesity affects hundreds of millions worldwide and is a major risk factor for heart disease, diabetes, and other chronic conditions