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It speeds up repigmentation while minimizing exposure to healthy skin

Trial FLOW (Perkovic et al., NEJM 2024) Design Phase 3 / event-driven Population 3,533 adults with T2D and CKD Key result 24% reduction in kidney disease progression and CV death (HR 0.76

While some metabolic adaptation still occurs, the direct appetite suppression provided by the medication means that the ghrelin increase is less impactful

Bantam chickens are injected with half the dose as above

This persistent risk has been attributed to additional factors, such as triglyceride-rich lipoproteins, remnant cholesterol, lipoprotein(a), and chronic inflammation