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If long-term storage of a reconstituted vial is needed, a single freeze is preferable to cycling

However, dose escalation must be balanced against potential adverse effects, particularly gastrointestinal symptoms such as nausea, vomiting and diarrhoea, which are usually mild-to-moderate, often transient, and typically dose-related

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Hydrolysis: HSL hydrolyzes triglycerides into free fatty acids (FFAs) and glycerol, which are then exported from the cell into the bloodstream to be used as fuel

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Tumour lysis syndrome (TLS) : May occur early in treatment, affecting renal and cardiac function