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262,263 GLP-1 regulates energy balance and food intake by acting on specific brain regions, especially the hypothalamus, a key area responsible for hunger and fullness sensations

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Certain findings indicate that DSIP may initially cause arousal in the early stages of rest followed by sedative effects later, suggesting a possible role in balancing or stabilizing disrupted sleep cycles

doi: 10.1007/s00415-009-0088-y, 30

A year later Edward Albert Sharpey-Schafer, a British physiologist then at University College London (UCL), suggested the pancreatic islets could have a role in controlling the level of blood sugar