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Additionally, gagunin D, a highly oxygenated diterpenoid from the marine sponge Phorbas sp., was also found to exhibit anti-melanogenic properties by downregulating the expression of proteins associated with melanosome transfer, including Rab27A, MLPH and myosin Va (133)

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References Coskun, T., Sloop, K.W., Loghin, C., Alsina-Fernandez, J., Urva, S., Bokvist, K.B., Cui, X., Briere, D.A., Cabrera, O., Roell, W.C., Kuchibhotla, U., Moyers, J.S., Benson, C.T., Gimeno, R.E., DAlessio, D.A., & Haupt, A

Research has also examined its role in circadian rhythm signaling and melatonin-related pathways , which are central to sleepwake regulation and endocrine timing in experimental systems