The half-life of drug was (t] /2 ) was calculated by 0.693/k
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In Denmark, about 70% of people who use weight loss medications are women and so it is inevitable that some may take it without realizing they are pregnant. However, she said more research is needed, and it is still too early to change the recommendation that GLP-1 RAs should be stopped before pregnancy, or to change counseling based on the reason the drugs were prescribed
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Exclusion criteria included polycystic ovarian syndrome (defined as female sex and age under 40 years at the time of first metformin prescription), immigration within the last 10 years, age over 95 years, an eGFR measurement below 30 mL/min/1.73 m 2 within the year before the index date, an ICD code indicating heart failure within the last 10 years (Table S2), missing prebaseline HbA1c data, an HbA1c level below 42 mmol/mol, or a diagnosis of gestational diabetes (DO244)
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