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Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI (2013) Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

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There is also discussion in the same Medical News Today article that standard trials escalate doses monthly mainly to optimize effect under defined trial conditions, but that in real-world practice, individuals differ widely in sensitivity, metabolism, side effect profile, etc

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doi: 10.1038/mp.2016.196 25 ChenJJGalluzziL