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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

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After 24 h, media were removed, and cell test compounds ( 50ac , at concentrations of 1 nM, 3 nM, 10 nM, 30 nM, 100 nM, 300 nM, 1 M, 3 M, 10 M or 30 M with 0.3% DMSO

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10.1073/pnas.1013964107 Proc