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The 14.9% efficacy ceiling at the approved dose is nearly 10 percentage points below what Retatrutide achieves

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Apart from intrinsic signaling, the TME shapes CSCs behavior and mechanical cures from ECM further modulates CSC fate, with poor stiffness enhancing stemness and high stress leading to quiescence via distinct integrin-dependent pathways

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From traditional medicine to advanced therapeutics: the renaissance of phyto-nano interventions in psoriasis