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Neurology 64 , 713715 (2005)

Practical Guidance for Aesthetic Practices Medical aestheticians wishing to use peptides in their work must first understand the correct application techniques and treatment approaches

The cataplerotic reactions that involve conversion of PEP to pyruvate in the cytosol then pyruvate to oxaloacetate (OAA) then OAA to aspartate in the mitochondria then aspartate back to OAA in the cytosol and OAA back to PEP constitute what is referred to as pyruvate cycling

Significant Side Effects: While we employ physician-supervised strategies to mitigate them (like slow, customized titration), some patients find that the gastrointestinal side effects (nausea, vomiting, diarrhea, constipation, reflux) outweigh the benefits

The transition back involves a gradual readjustment process that affects appetite, blood sugar control, and weight management

doi: 10.1002/bio.4715 21 HuoG.LinY.LiuL.HeY.QuY.LiuY.et al