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348 Similarly, in human chondrocytes stimulated by TNF, GLP-1 analogs (such as liraglutide) showed an anti-catabolic effect, reducing the mRNA expression of MMP-3, MMP-13, and ADAMTS5

Without tracking, the decision often comes down to how you feel in the moment, which is not a reliable guide

Our patients at Centra Internal Medicine noticed modest weight reduction within the first four weeks of treatment

There is no doubt that the target sites for GLP-1 or GLP-1RAs to exert those functions are located in the brain

Preferences influencing choice of additional medications may include blood pressure (BP) level, blood glucose level, potassium level, eGFR and kidney failure risk equation (KFRE) projected risk, weight management, and contraindications to medications or adverse effects (Table 2)

Overall, discontinuation rates due to side effects are low across all options