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Dependency on Maintenance Doses: Continuous maintenance may be required to preserve the whitening effect, adding to long-term costs

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The formation of gamma-glutamylcysteine is the rate-limiting reaction in GSH synthesis and is feedback inhibited by GSH itself, a mechanism responsible for the regulation of cellular GSH concentration

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Although the traditional view holds that the BBB separates peripheral and CNS sources of ApoE, emerging evidence indicates that peripheral ApoE exerts significant regulatory effects on CNS function [86]

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