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Tirzepatide: A Systematic Update

doi: 10.1136/bmj.a1344 128 SpenceJ

However, rodent studies have shown that long-term Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) exposure can induce proliferative changes, including thyroid C-cell tumors and epithelial cell hyperplasia, through GLP-1Rmediated pathways, raising concerns about potential mitogenic effects in other tissues

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Holman RR, Bethel MA, Mentz RJ et al (2017) Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

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