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10.1210/jc.2016-2007 165 KovameesO.ShemyakinA.ErikssonM.AngelinB.PernowJ

Cumulative receptor saturation occurs when IGF-1 LR3 is dosed before prior clearance, producing an anabolic ceiling where additional IGF-1 binding no longer increases mTOR activation and instead drives glucose into adipose tissue

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