For constipation: increase fiber intake gradually, stay hydrated, and maintain physical activity
Metformin passes into breast milk in minimal amounts, whilst insulin molecules are too large to transfer significantly and would be digested in the infant's gastrointestinal tract
In Phase 2 and early Phase 3 trials, the most common side effects were gastrointestinal, including nausea, diarrhea, vomiting, and constipation, which were generally mild-to-moderate and dose-dependent
When to contact your GP: Persistent severe nausea or vomiting that prevents adequate fluid intake Signs of dehydration (dizziness, dark urine, reduced urination) Severe abdominal pain that could indicate pancreatitis Symptoms of very low blood sugar (confusion, sweating, trembling) if taking other diabetes medications Blood pressure readings consistently below 90/60 mmHg or above your target range Blood pressure readings of 180/120 mmHg or higher, especially with symptoms such as severe headache, chest pain, or vision problems (seek same-day medical assessment) Any new or concerning symptoms Your healthcare team may adjust your blood pressure medications if your readings improve significantly
The metabolic health benefits of these medications extend well beyond weight loss
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