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Chronic Weight Management: Acts as a highly effective, long-term intervention for adults with obesity (BMI 30) or overweight profiles (BMI 27) accompanied by weight-related health conditions

Jiang and Lin, 2007[59]

A statistically significant greater proportion of the patients randomized to QSYMIA than placebo achieved 5% and 10% weight loss

10.1056/NEJMoa2307563 57 LiuJ.WeiL.WangZ.SongS.LinZ.ZhuJ.et al (2020a)

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Since many metabolites of phase I are too lipophilic to be retained in the kidney tubules, a subsequent conjugation reaction with an endogenous substrate, such as glucuronic acid, acetic acid, sulfuric acid or an amino acid, results in formation of more polar and hydrophilic compounds that are sufficiently polar to be excreted by the kidneys