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In women, these deficiencies may contribute to luteal phase defects, while men may see reduced testosterone levels and impaired sperm motility

Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity

When people need fewer pain medications, that signals genuine functional improvement rather than just numerical change on a pain scale

Levels of the hormone rise slowly, then spike to signal fullness

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism editorial team

Spring 2026 is an ideal time to consult, as patients who began GLP-1 medications in late 2025 are now approaching stable weights and can plan body contouring with sufficient recovery time before summer