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in effect, the sensory filter disintegrates : Based on this literature and observations from our own laboratory and others on the role of astroglial cells in the fine-tuning of glutamate neurotransmission we present the hypothesis that the proinflammatory cytokines tumor necrosis factor- , IL-1 and IL-6 could be involved in the pathophysiology of mental fatigue through their ability to attenuate the astroglial clearance of extracellular glutamate, their disintegration of the blood brain barrier, and effects on astroglial metabolism and metabolic supply for the neurons, thereby attenuating glutamate transmission
doi: 10.53388/ghr2023-03-078 265 WuJGuanFHuangHChenHLiuYZhangSet al
Perilipin 1, a lipid droplet scaffold protein that coordinates interactions with ABHD5 and HSL Perilipin 1 (PLIN1), initially discovered by the group of Constantine Londos, is the major adipocyte perilipin/ADRP/TIP47 (PAT) protein (35) that functions as a scaffold to organized protein-protein interactions on the surface of LDs (36)
Healthcare providers should stay informed of evolving research in this area and consider how adjunctive metabolic therapies might benefit their patients struggling with obesity and metabolic syndrome
111 PerkovicV.JardineM
Dymek, M., Olechowska, K., Hc-Wydro, K., & Sikora, E
