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Retatrutide for managing overweight and obesity [ID6644] Awaiting Development

Optic atrophy is the degeneration of the optic nerve due to ischemia, trauma, genetic conditions, glaucoma, optic neuritis, or toxic effects

Ozempic (semaglutide) is a GLP-1 receptor agonist requiring refrigeration (2C8C) for unopened pens to maintain peptide stability and therapeutic potency

Importantly, either genetic silencing of NCOA4 or treatment with the iron chelator deferoxamine (DFO) significantly attenuated these pathological changes, resulting in over 60% improvement in neuronal survival (Plascencia-Villa and Perry, 2021)