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As a result, recent strategies have been shifted toward developing non-invasive drug delivery methods to improve brain drug delivery, including the use of prodrugs, nanoparticles, focused ultrasound, and intranasal (IN) delivery methods (Terstappen et al., 2021)

Ca 2+ is not metabolized and an overload of mitochondrial Ca 2+ may break down the electrochemical proton gradient resulting in a deficit of ATP followed by necrosis [89]

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