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A patient using B12 shots for weight loss alone typically does not, because vitamin support does not reduce appetite or change how the body regulates weight

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Additionally, a diet low in folic acid or other key vitamins may also affect your body's ability to use B12 effectively

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In REDEFINE 2, which included participants with type 2 diabetes (a population that typically shows lower weight loss with any intervention), CagriSema achieved 13.7% weight loss compared to 3.4% with placebo

Other, rare side effects of sermorelin include (10): Shortness of breath Facial flushing Nausea Headache Sleepiness Difficulty sleeping Trouble sitting still Muscle or joint pain If you take sermorelin with TRT, you may also experience side effects from the testosterone therapy