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For dose responses, a full GLP-1 curve was included to establish the assay E max with curve fitting to a four-parameter fit

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In the RT structure, the cyano group at the position of the Michael acceptor enables fast reaction kinetics, the four-membered azetidine ring improves quantum yield and photostability 17 , and the two carboxylic acid groups ensure aqueous solubility and reduce probe binding to hydrophobic cellular structures

Glucagon-like Peptide-1 Receptor Agonist, Exendin-4, Reduces Reinstatement of Heroin-Seeking Behavior in Rats

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