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GLP-1 receptor agonists achieve weight loss through several mechanisms: Slowing gastric emptying, which promotes feelings of fullness Reducing appetite by acting on brain centres that control hunger Improving insulin secretion and reducing glucagon release Potentially affecting food reward pathways in the brain According to NICE Technology Appraisal guidance (TA875 for semaglutide/Wegovy and TA664 for liraglutide/Saxenda), these medications may be considered for weight management in adults with a BMI of at least 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean family backgrounds) with at least one weight-related comorbidity

Most GLP-1RA scripts were for dulaglutide ( n = 244) followed by semaglutide ( n = 241)

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Long-term side effects of the drug may include gastrointestinal damage, gallstone issues, and urinary tract infections