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They were absolutely three alarming complications, but then we have enough evidence on all three to believe that we really do not have increased risk of any of them. However, one organ that has been affected by GLP-1 agonists in randomized trials is the gallbladder (7)

The primary end-point event (myocardial infarction/stroke) in 305 patients on alogliptin therapy was 11.3% in comparison with placebo (11.8%) (hazard ratio, 0.96