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The diffuse nature of the pigmentation across both upper and lower gingival tissues, without the characteristic multicomponent dermoscopic pattern seen in 75% of mucosal melanomas, suggests this is more likely benign melanosis rather than malignant transformation [15]

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13 Although studies have found a protective role for TREM2 in response to amyloid pathology, the opposing roles for TREM2 have been reported in mouse models of tauopathies