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Pure creatine monohydrate shouldnt noticeably affect insulin in most people

A bunch of mitochondrial proteins have succinylation modification, such as UCP1 in thermogenic function, GLUD1 in glutamate metabolism, SDH in ETC, the TCA cycle, GLS2 and CPS1 in glutaminolysis, ECHA and VLCAD in FAO, HMGCS2 in ketogenesis and SHMT2 in serine catabolism

doi: 10.1023/a:1006317125454 52 KimJEFinlayGJBaguleyBC

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Among 81,617 patients with existing substance-use disorders, the odds of related emergency department visits during the next three years were 31% lower for those on GLP-1s

Urine gas chromatography-mass spectrometry analysis suggests increased 3-hydroxypropionic acid and methylcitric acid, and blood tandem mass spectrometry analysis of dried blood spots of acylcarnitine suggests significantly elevated propionylcarnitine [14]