High-level, it does three important things: Tells your pancreas to release insulin (which helps manage blood sugar ) Slows gastric emptying (which keeps you full longer) Sends a satiety signal to your brain that says youve had enough Now, medications like Ozempic and Wegovy are synthetic versions of GLP-1 at levels roughly 1,000 times higher than what a meal produces
GLP-1 is also responsible for a multitude of extra-pancreatic effects that made its pharmacological development even more interesting
Common side effects include nausea, diarrhea, vomiting, constipation, stomach discomfort, rash or pain around the injection site, fatigue, burping, hair loss, and gastroesophageal reflux disease
Oral Contraceptives: Tirzepatide (Zepbound/Mounjaro) may reduce efficacy due to slowed gastric emptying, especially during initiation and escalation
Malhotra points out that studies have repeatedly shown CPAP fails to improve cardiovascular morbidity and mortality, so treating the underlying cause of the sleep apnea might be required to really see the benefits. Malhotra says, Everything went in the right direction
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